Synthesis, characterization, lipoxygenase, and tyrosinase inhibitory activities of non- cytotoxic titanium(III) and (IV) hydrazide complexes

ABSTRACT. Ti(III) and (IV) hydrazide complexes were synthesized, characterized, screened for their tyrosinase lipoxygenase inhibitory cytotoxic activities. The geometry of is tentatively assigned as octahedral. Magnetic moments found around 1.7 B.M. electronic spectral transition in the range 495-518 nm. Evaluation Ti(IV) activities revealed varying inhibition potential. Hydrazide ligands inactive against tyrosinase, while significant activity was observed (LOX). Good to moderate by both enzymes. At same time, promising results obtained enzymes suggesting broad application inhibitors. Complex 4d possess negative inhibition, thus behaving a activator. docking showed good correlation between complex experimental binding energies. Cytotoxic investigation non-toxicity normal cells.
 
 KEY WORDS: Titanium(III) titanium(IV) complex, Tyrosinase, Lipoxygenase, Inhibition, Molecular docking, Cytotoxicity
 Bull. Chem. Soc. Ethiop. 2023, 37(2), 315-333. DOI: https://dx.doi.org/10.4314/bcse.v37i2.6